Migraine
Pain
Anxiety
Insomnia
Nausea
Relief In Seconds
The Problem
Medicine today works too slowly. Pills take 1-4 hours to relieve conditions like migraine, pain, and nausea.
Miist’s Solution
Miist has developed a new category of medicine that can treat these conditions in 30 seconds: inhaled microparticles.
The Science
Oral Therapies Are Limited By Slow
Digestion
Pills take 1-4 hours to digest. This significantly delays their onset, reduces their efficacy, and leaves patients
suffering with their symptoms for hours.
Miist’s Inhaled Microparticles Deliver Relief In Seconds
Human lungs have evolved to absorb inhaled air in seconds. Miist’s novel inhaled microparticles hijack this evolved pathway, reaching the bloodstream and taking effect in 30 seconds.
Fast Relief Means Greater Efficacy For Patients
By putting our microparticles to work in the body within 30 seconds, we’re able to treat conditions the minute they
start, when medicine is most effective.
Our Microparticle Approach Is Novel
Inhaled medicines exist today, but take the form of large particles that get trapped in the lung, rather than rapidly absorbed through it. Therefore, they can’t be used to treat systemic conditions like migraine.
Platform Features
Speed
Peak plasma levels reached in less than 30 seconds
Ease
Instant relief in the convenience of a breath
Safety
Produces sterile aqueous particles using vibration, not heat
Platform & Pipeline
We’re Building a Portfolio of Instant-Acting Therapies, Starting With Migraine
Microparticle Inhaler
Platform Technology
In a 10-patient clinical trial, using a well known reference molecule, we demonstrated that our microparticles were fully absorbed (reached Cmax) within 30 seconds.
Patients achieved 92% symptom relief within 2 minutes, demonstrating that our rapid acting microparticles deliver strong efficacy.
MST02
Migraine
Americans live with migraine
Annual spend on migraine pills
Failure rate of migraine pills
Cause of disability for women
40 million Americans live with migraines, 4 million of which experience 15+ migraine attacks per month. The primary treatment method for migraine attacks are triptan and gepant pills. Migraine patients spend ~$3.5 billion per year on these pills, yet they fail to fully relieve ~70% of severe migraine attacks.
Migraine pills fail because they are too slow. Migraines start becoming unresponsive to medication only 30-60 minutes after they start, yet migraine pills take 2-4 hours to reach their full effect.
MST-02 is Miist’s migraine inhaler, which leverages our microparticle technology. It has been tested in 2 canine studies and demonstrated rapid onset and a strong safety profile. MST-02 is being advanced into a Phase 1/2 clinical trial, where we intend to show that it is a clear best-in-class therapy that works ~250x faster and is significantly more effective than today's migraine pills.
Meet our team
Eric Ezerins & Dalton Signor
Cofounders, Head of Technology & CEO
Eric and Dalton are long time friends who founded and led Miist from an idea to a clinical stage therapeutics company in under 2 years.
Dougal Thring
VP of Clinical Development
Dougal has led multiple therapeutic programs and overseen 300 clinical trials throughout his career. At Miist he leads all preclinical testing, clinical trials, and drug product development.
Thor Wilbanks
Head of Applied Physics
Thor is a Physics PhD from UC Berkeley with 30 years in industry developing advanced laser systems, battery technologies, and aerosol drug delivery systems.
Miist Lab
Alameda, CA
Miist has a 2,000 sq ft world class aerosol lab and an incredible team of chemists and engineers developing our therapies.
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